Telomeres and essential hypertension
نویسندگان
چکیده
منابع مشابه
Telomeres and essential hypertension.
The dynamics of telomere attrition in human beings might shape the course of age-dependent, complex genetic traits. One of these traits is essential hypertension. Age-dependent telomere attrition could lead to critically shortened telomeres and aneuploidy (ie, the loss or gain of chromosomes) with a resultant mosaicism that will be variably expressed in different cells and tissues. The chromoso...
متن کاملTelomeres, Essential Hypertension, and Vascular Aging
There is considerable evidence that essential hypertension is closely linked to the growth, development, and aging of human beings. It is imperative, therefore, to introduce biological indicators of growth and aging into models developed to provide a better understanding of the etiology of essential hypertension. One of these indicators may well be the age-dependent telomere attrition rate in s...
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There is considerable evidence that essential hypertension is closely linked to the growth, development, and aging of human beings. It is imperative, therefore, to introduce biological indicators of growth and aging into models developed to provide a better understanding of the etiology of essential hypertension. One of these indicators may well be the age-dependent telomere attrition rate in s...
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T elomeres, the specialized nucleoprotein structures present at the ends of linear chromosomes, function to prevent natural chromosomal termini from activating the DNA damage response and becoming substrates for inappropriate DNA repair. Telomeres are organized into lariat-like structures known as tloops, which are formed by the invasion of the terminal G-rich 3 telomeric overhang into the prox...
متن کاملTelomeric RNAs are essential to maintain telomeres
Telomeres are transcribed generating long non-coding RNAs known as TERRA. Deciphering the role of TERRA has been one of the unsolved issues of telomere biology in the past decade. This has been, in part, due to lack of knowledge on the TERRA loci, thus preventing functional genetic studies. Here, we describe that long non-coding RNAs with TERRA features are transcribed from the human 20q and Xp...
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ژورنال
عنوان ژورنال: American Journal of Hypertension
سال: 1999
ISSN: 0895-7061
DOI: 10.1016/s0895-7061(98)00202-7